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Pax6132-14Neu
Radiation induced Allele Detail
Nomenclature
Symbol: Pax6132-14Neu
Name: paired box 6; 132-14, Neuherberg
MGI ID: MGI:1856585
Synonyms: Apyc, Cat4a, Cat4Apcat1-1
Gene: Pax6  Location: Chr2:105668900-105697364 bp, + strand  Genetic Position: Chr2, 55.31 cM
Pax6132-14Neu/Pax6+ and Pax6132-14Neu/Pax6132-14Neu histological adult eye sections.

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  (102 x C3H)F1
Mutation
description
Allele Type:    Radiation induced
Mutation:    Single point mutation
 
Mutation detailsMice contain a T to A transversion at position 1099 that results in an amino acid substitution of isoleucine for phenylalanine at position 272 (F272I). (J:137541)
Inheritance:    Semidominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax6 Mutation:  58 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Anterior Pyramidal Cataract in heterozygous mice (J:6686)
References
Original:  J:6686 Kratochvilova J, Dominant cataract mutations detected in offspring of gamma-irradiated male mice. J Hered. 1981 Sep-Oct;72(5):302-7
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/16/2017
MGI 6.07
The Jackson Laboratory