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Foxn1nu-Y
Spontaneous Allele Detail
Nomenclature
Symbol: Foxn1nu-Y
Name: forkhead box N1; nude Yurlovo
MGI ID: MGI:1856502
Gene: Foxn1  Location: Chr11:78248403-78277384 bp, - strand  Genetic Position: Chr11, 46.74 cM
Mutation
origin
Strain of Origin:  101/HY
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA point mutation resulting in the C-to-T transition at nucleotide 1051 (accession# X81593) located in exon 7, leads to the replacement of an arginine with a cysteine at amino acid 320 (p.R320C). Although mutant protein is detectable in the nucleus, there was no detectable activation of the Krt2-18 target gene. (J:61394)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxn1 Mutation:  97 strains or lines available
References
Original:  J:4060 Ignat'eva EL, et al., Athymic Mice of Inbred Strain 101/Hy with a New Allele at the Nude Locus. Biull Eksp Biol Med. 1992;113(1):111-4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory