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Spontaneous Allele Detail
Symbol: Aiapy
Name: nonagouti; intracisternal A particle yellow
MGI ID: MGI:1856403
Synonyms: A*
Gene: a  Location: Chr2:154950599-155051012 bp, + strand  Genetic Position: Chr2, 76.83 cM
Strain of Origin:  (C57BL/6J x C3H/HeJ)F1/J
Allele Type:    Spontaneous
Mutation:    Transposon insertion
Mutation detailsSouthern blot analysis showed that this allele is the result of a 5.2 kb intracisternal A particle (IAP) transposon insertion in an antisense orientation immediately 5' of the first coding exon of the agouti gene. This results in ectopic and differential expression of agouti protein via utilization of a cryptic promoter within the IAP 5' long terminal repeat (LTR) and variable methylation. Methylation assay results indciate that the agouti and yellow mosaic phenotype characteristic of this allele is due to differential epigenetic methylation of the IAP. mRNA from this allele was found to be ectopically over-expressed in several adult tissues from heterozygous mice. The transcript was the same size as mRNA from the wild-type allele. The mutation occurred in a C3H/HeJ A allele. (J:18848, J:21244, J:79708)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any a Mutation:  416 strains or lines available

Genbank ID for this allele: L33247, L33248

Original:  J:18848 Michaud EJ, et al., Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage. Genes Dev. 1994 Jun 15;8(12):1463-72
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory