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Targeted Allele Detail
Symbol: Egfrtm1Mag
Name: epidermal growth factor receptor; targeted mutation 1, Terry Magnuson
MGI ID: MGI:1856402
Synonyms: EGFR-, Egfrm1Cwr, ErbB1-
Gene: Egfr  Location: Chr11:16752203-16913907 bp, + strand  Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
Germline Transmission:  Earliest citation of germline transmission: J:26833
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced 155 bp containing part of exon 2. Aberrant splicing of the targeted exon was detected joining exon 1 to either exon 3 or exon 5. The former splicing event creates a nonsense protein. Although the latter splicing event produes a truncated mRNA, no protein or phosphorylation activity was detectable. (J:26833)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 25 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Egfr Mutation:  14 strains or lines available
Original:  J:26833 Threadgill DW, et al., Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science. 1995 Jul 14;269(5221):230-4
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory