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Spontaneous Allele Detail
Symbol: Cacng2stg-wag
Name: calcium channel, voltage-dependent, gamma subunit 2; waggler
MGI ID: MGI:1856386
Synonyms: wag
Gene: Cacng2  Location: Chr15:77875948-78004228 bp, - strand  Genetic Position: Chr15, 36.92 cM
Strain of Origin:  MRL/MpJ-Faslpr/J
Allele Type:    Spontaneous
Mutation:    Other
Mutation detailsThe phenotype of the waggler is associated with aberrant splicing residing in the first intron. Like the stargazer allele, a RT-PCR analysis demonstrated that in addition to aberrant transcripts, some normally spliced mRNA was detected, suggesting that this mutation does not represent a complete null allele. (J:48966)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cacng2 Mutation:  22 strains or lines available
Waggler is a second recessive mutation at the Cacng2 locus that arose in 1988 in the MRL/MpJ-Tnfrsf6 colony maintained at The Jackson Laboratory by Dr. Charles Sidman. Mutant homozygotes are characterized by whole body tremor, an unstable gait, and growth retardation. Hydrocephaly occurs occasionally. Hearing tests by Dr. Lawrence Erway of the University of Cinncinnati showed that the mutant was not deaf. Both sexes breed; no gross neuroanatomical or histopathologic lesions have been found (J:14313).
Original:  J:14311 Sweet HO, et al., Waggler (wag). Mouse Genome. 1991;89:552-53
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory