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Faslpr
Spontaneous Allele Detail
Nomenclature
Symbol: Faslpr
Name: Fas (TNF receptor superfamily member 6); lymphoproliferation
MGI ID: MGI:1856334
Synonyms: Fas-, Fas-def, lpr, MRL/lpr, Tnfrf6lpr, Tnfrsf6lpr, Tnfrsf6lpr
Gene: Fas  Location: Chr19:34290659-34327770 bp, + strand  Genetic Position: Chr19, 29.48 cM
control and Faslpr/Faslpr

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  MRL/Mp
Mutation
description
Allele Type:    Spontaneous
Mutation:    Other
 
Mutation details
Inheritance:    Recessive
Phenotypes
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Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 18 strains available      Cell Lines: 0 lines available
Carrying any Fas Mutation:  37 strains or lines available
Notes
Faslpr, lymphoproliferation, recessive. This mutation was found during inbreeding of a strain MRL/Mp derived from crosses among strains LG, AKR, C3H, and C57BL/6. The resemblance has led to extensive use of Faslpr mice in attempts to determine the etiology of SLE and to evaluate therapies. However, the human APT1 gene (OMIM 134637) encodes the FAS antigen; Tnfrsf6 is not the homolog of the human (SLE) gene. The Cd72c haplotype is a modifier of Faslpr-induced autoimmune disease. J:204782

References
Original:  J:28885 Murphy ED, et al., Autoimmunity and lymphoproliferation: Induction by mutant gene lpr, and acceleration by a male-associated factor in strain BXSB mice, in Genetic Control of Autoimmune Disease. 1978:207-20.
All:  762 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory