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Col1a2oim
Spontaneous Allele Detail
Nomenclature
Symbol: Col1a2oim
Name: collagen, type I, alpha 2; osteogenesis imperfecta
MGI ID: MGI:1856327
Synonyms: oim
Gene: Col1a2  Location: Chr6:4504814-4541543 bp, + strand  Genetic Position: Chr6, 1.81 cM
Radiograph comparison of wild type and Col1a2oim/Col1a2oim mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  (C3H/HeJ x C57BL/6JLe)F2
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation details
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col1a2 Mutation:  6 strains or lines available
Notes
Heterozygotes exhibit phenotypic similarity to human syndrome: mild form of osteogenesis imperfecta (J:38013).

References
Original:  J:4348 Chipman SD, et al., Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1701-5
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory