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Btkxid
Spontaneous Allele Detail
Nomenclature
Symbol: Btkxid
Name: Bruton agammaglobulinemia tyrosine kinase; X linked immune deficiency
MGI ID: MGI:1856317
Synonyms: xid
Gene: Btk  Location: ChrX:134542336-134583570 bp, - strand  Genetic Position: ChrX, 56.18 cM
Mutation
origin
Strain of Origin:  CBA/HN
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsThe C to T transition point mutation at position 219 is predicted to change amino acid 28 from an arginine to a cysteine in the encoded protein. (J:13209)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Btk Mutation:  12 strains or lines available
References
Original:  J:6296 Berning AK, et al., Mapping of the X-linked immune deficiency mutation (xid) of CBA/N mice. J Immunol. 1980 Apr;124(4):1875-7
All:  145 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory