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Spontaneous Allele Detail
Symbol: Yaa
Name: accelerated autoimmunity and lymphoproliferation transposition; accelerated autoimmunity and lymphoproliferation
MGI ID: MGI:1856277
Synonyms: Is(XOfd1-Mid1;Y)1Mp, Tp(X;Y)1Ekw
Gene: Yaa  Location: unknown  Genetic Position: ChrY, Syntenic
Strain of Origin:  SB/Le
Allele Type:    Spontaneous
Mutations:    Insertion, Translocation
Mutation detailsAn approximately 4 MB region of the X chromosome that includes at least 13 known genes (spanning from Ofd1 to Mid1) was translocated to the Y chromosome adjacent to the pseudoautosomal region. Increased RNA expression of Msl3, Tlr7, Tmsb4x and Rab9 was detected in follicular B cells. (J:109758, J:111064, J:140028)
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Carrying this Mutation:  Mouse Strains: 10 strains available      Cell Lines: 0 lines available
Carrying any Yaa Mutation:  13 strains or lines available
The accelerated progression in males of the autoimmune phenotype of the BXSB/Mp recombinant inbred (RI) strain is associated with the Y Chromosome, which was derived from strain SB/Le. After this discovery, reciprocal crosses between SB/Le and C57BL/6J, the inbred progenitors of BXSB/Mp, demonstrated similar acceleration of autoimmune progression in F1 males whose Y Chr was inherited from SB/Le. (J:6235)

In congenic C57BL/6 Yaa mice expression of Tlr7 is increased 2-fold.

Original:  J:6235 Murphy ED, et al., A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum. 1979 Nov;22(11):1188-94
All:  66 reference(s)

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MGI 5.21
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