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Yaa
Spontaneous Allele Detail
Nomenclature
Symbol: Yaa
Name: accelerated autoimmunity and lymphoproliferation transposition; accelerated autoimmunity and lymphoproliferation
MGI ID: MGI:1856277
Synonyms: Is(XOfd1-Mid1;Y)1Mp, Tp(X;Y)1Ekw
Gene: Yaa  Location: unknown  Genetic Position: ChrY, Syntenic
Mutation
origin
Strain of Origin:  SB/Le
Mutation
description
Allele Type:    Spontaneous
Mutations:    Insertion, Translocation
 
Mutation detailsAn approximately 4 MB region of the X chromosome that includes at least 13 known genes (spanning from Ofd1 to Mid1) was translocated to the Y chromosome adjacent to the pseudoautosomal region. Increased RNA expression of Msl3, Tlr7, Tmsb4x and Rab9 was detected in follicular B cells. (J:109758, J:111064, J:140028)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 10 strains available      Cell Lines: 0 lines available
Carrying any Yaa Mutation:  13 strains or lines available
References
Original:  J:6235 Murphy ED, et al., A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum. 1979 Nov;22(11):1188-94
All:  66 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory