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KitW-v
Spontaneous Allele Detail
Nomenclature
Symbol: KitW-v
Name: KIT proto-oncogene receptor tyrosine kinase; viable dominant spotting
MGI ID: MGI:1856266
Synonyms: KitWv, W', W2, Wv, Wv
Gene: Kit  Location: Chr5:75574987-75656722 bp, + strand  Genetic Position: Chr5, 39.55 cM
KitW-v/Kit+ mouse

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  silvered black strain
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA C-to-T point mutation at coding nucleotide 1979 (transcript NM_021099) results in a threonine to methionine substitution at amino acid 660 (p.T660M). (J:10528, J:24351)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 118 assay results
In Structures Affected by this Mutation: 26 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 11 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  96 strains or lines available
References
Original:  J:2447 Little CC, et al., The occurrence of a dominant spotting mutation in the house mouse. Proc Natl Acad Sci U S A. 1937 Oct;23(10):535-537
All:  409 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory