About   Help   FAQ
KitW-f
Spontaneous Allele Detail
Summary
Symbol: KitW-f
Name: KIT proto-oncogene receptor tyrosine kinase; fertile dominant spotting
MGI ID: MGI:1856261
Gene: Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: KitW-f page
Mutation
origin
Strain of Origin:  C3H/HePas
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsAnalysis of cDNA showed this allele comprises an A-to-T transversion at coding nucleotide 2446 (transcript NM_021099) in the tyrosine kinase domain, producing a change from arginine to tryptophan at position 816 (p.R816W). (J:27513)
Inheritance:    Semidominant
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  180 strains or lines available
References
Original:  J:6187 Guenet JL, et al., Fertile dominant spotting in the house mouse. J Hered. 1979 Jan-Feb;70(1):9-12
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory