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KitW-73J
Spontaneous Allele Detail
Nomenclature
Symbol: KitW-73J
Name: KIT proto-oncogene receptor tyrosine kinase; dominant spotting 73 Jackson
MGI ID: MGI:1856255
Gene: Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Mutation
origin
Strain of Origin:  DBA/2J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsDirect sequence of this allele and comparison with normal c-kit indicated a nonsynonymous coding mutation of a C-to-A point mutation in ATP biding loop consensus sequence of the kinase domain that result in replacement of the alanine with an aspartate residue at amino acid 605 position (p.A605D). (J:151778)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  149 strains or lines available
References
Original:  J:16572 Sweet HO, et al., New W allele W<73J>. Mouse Genome. 1990;86:239
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory