Slc45a2^Uw-dbr
Spontaneous Allele Detail

Summary

• Symbol: Slc45a2^Uw-dbr
• Name: solute carrier family 45, member 2; underwhite dominant brown
• MGI ID: MGI:1856227
• Synonyms: dbr
• Gene: Slc45a2 Location: Chr15:11000807-11029319 bp, + strand Genetic Position: Chr15, 5.4 cM
• Alliance: Slc45a2^Uw-dbr page

Slc45a2^Uw-dbr/+ and Slc45a2^Uw-dbr/Slc45a2^Uw-dbr

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: B10.PL-H2^u/(73NS)Sn

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: Molecular analysis reveals a G-to-A transition in codon 153, resulting in the substitution of a highly conserved aspartic acid with asparagine (p.D153N). The substitution occurs near the cytoplasmic face of transmembrane domain 4, adjacent to the loop containing the sucrose transporter signature sequence. (J:72440)
• Inheritance: Semidominant

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc45a2 Mutation: 55 strains or lines available

References

• Original: J:13967 MacPike A, et al., New coat color mutations, Dbr and cht. Mouse News Lett. 1984;70:86
• All: 5 reference(s)