Eda^Ta-25H
Radiation induced Allele Detail

Summary

• Symbol: Eda^Ta-25H
• Name: ectodysplasin-A; tabby 25 Harwell
• MGI ID: MGI:1856203
• Synonyms: Ta25H, Ta^25H
• Gene: Eda Location: ChrX:99019212-99444366 bp, + strand Genetic Position: ChrX, 43.59 cM
• Alliance: Eda^Ta-25H page

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intergenic deletion
• Mutation details: Southern blot analysis shows that the deletion comprising Ta-25H extends, minimally, 1.5cM and deletes the locus Ar as well as Eda but does not delete the X-inactivation center Xic. (J:11266, J:11630, J:42614)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eda Mutation: 34 strains or lines available

Notes

Eda^Ta-25H. A female with the typical tabby phenotype resulted from 6 Gy spermatogonial irradiation. She produced Eda^Ta-25H/+, +/+, and hemizygous Eda^Ta-25H daughters, but only hemizygous +/Y males. The Eda^Ta-25H hemizygous daughters were chromosomally XY, and, rather than ovaries, had abdominally located testes. This indicated a deletion of both the Eda and Ar loci, which was given the symbol Eda^Ta-25H as an allele at the tabby locus. There is a shortage of both heterozygous and hemizygous Eda^Ta-25H mice, and Eda^Ta-25H/+ heterozygous females tend to have smaller litters than their wild-type sibs. Heterozygotes (but not hemizygotes) often show skeletal defects (J:14235).

References

• Original: J:14235 Cattanach BM, et al., Ta^25H, a presumptive X Chromosome deletion. Mouse News Lett. 1989;83:160
• All: 5 reference(s)