Vsx2^or-2J
Spontaneous Allele Detail

Summary

• Symbol: Vsx2^or-2J
• Name: visual system homeobox 2; ocular retardation 2 Jackson
• MGI ID: MGI:1856113
• Gene: Vsx2 Location: Chr12:84616602-84642231 bp, + strand Genetic Position: Chr12, 39.28 cM
• Alliance: Vsx2^or-2J page

Mutation origin

• Strain of Origin: NOR/LtDn

Mutation description

• Allele Type: Spontaneous
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vsx2 Mutation: 23 strains or lines available

Notes

A remutation at the Chx10 locus occurred in NOR/LtDn, a genetically contaminated subline of the nonobese diabetic NOD/Lt strain. Eye phenotypes in homozygotes resemble the eye abnormalities reported in Chx10^or-J/Chx10^or-J homozygotes. NOR-Chx10^or-2J/Chx10^or-2J homozygotes of both sexes are infertile and show defective germ cell maturation. Chx10^or-J/Chx10^or-2J heterozygotes are fully fertile in both sexes (J:30714).

References

• Original: J:30714 Prochazka M, et al., or-2J; a new remutation at ocular retardation (or) associated with sterility. Mouse Genome. 1990;87:93
• All: 1 reference(s)