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Mitfmi-bw
Spontaneous Allele Detail
Nomenclature
Symbol: Mitfmi-bw
Name: melanogenesis associated transcription factor; black eyed white
MGI ID: MGI:1856089
Gene: Mitf  Location: Chr6:97784013-97998310 bp, + strand  Genetic Position: Chr6, 45.05 cM
Mutation
origin
Strain of Origin:  C3H
Mutation
description
Allele Type:    Spontaneous
Mutation:    Transposon insertion
 
Mutation detailsThis allele comprises a 7.2 kb novel L1 element insertion into intron sequences located between exons 3 and 4. This insertion reduces the amount of mRNAs for two splicing isoforms of this gene and abolishes expression of a third isoform. (J:56633)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Mitf Mutation:  65 strains or lines available
References
Original:  J:13071 Kreitner PC, Linkage studies in a new black-eyed white mutation in the house mouse (not W). J Hered. 1957;48:300-304
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory