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Lbric-J
Spontaneous Allele Detail
Nomenclature
Symbol: Lbric-J
Name: lamin B receptor; ichthyosis Jackson
MGI ID: MGI:1856064
Synonyms: icJ
Gene: Lbr  Location: Chr1:181815315-181842401 bp, - strand  Genetic Position: Chr1, 84.89 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Insertion
 
Mutation detailsThis phenotypic mutant was found to be allelic to ic by complementation testing. The mutation in the Lbric-J mouse was identified as 2 bp insertion at position 1088. This insertion results in a frame shift, changing amino acids 365-385, and creates a premature stop codon at amino acid position 386. (J:80915)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lbr Mutation:  36 strains or lines available
References
Original:  J:24755 Eicher EM, Spontaneous mutations - streaker (nu) and ichthyosis (ic). Mouse News Lett. 1976;54:40
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory