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Hbbd3th
Spontaneous Allele Detail
Nomenclature
Symbol: Hbbd3th
Name: hemoglobin beta chain complex; beta-thalassemia
MGI ID: MGI:1856047
Synonyms: betamajor, betaMDD, Hbbd3(th), Hbbth-1, Hbbth1, HbbUNC
Gene: Hbb  Location: unknown  Genetic Position: Chr7, Syntenic
Mutation
origin
Strain of Origin:  DBA/2J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Deletion
  Hbbd3th involves 1 genes/genome features (Hbb) View all
 
Mutation detailsA 3.7 kb region, including the entire beta major globin gene and 2 kilobases of 5' flanking region, is deleted. A novel approximately 66 bp sequence ending in a poly(A) stretch was found to bridge the deletion. (J:8395)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Hbb Mutation:  46 strains or lines available
References
Original:  J:7209 Skow LC, et al., A mouse model for beta-thalassemia. Cell. 1983 Oct;34(3):1043-52
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory