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Hbbd4
Chemically induced Allele Detail
Nomenclature
Symbol: Hbbd4
Name: hemoglobin beta chain complex; diffuse 4
MGI ID: MGI:1856044
Synonyms: Hbbc, polycythemia
Gene: Hbb  Location: unknown  Genetic Position: Chr7, Syntenic
Mutation
origin
Strain of Origin:  (T x 101/H)F1
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation details
Inheritance:    Not Specified
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hbb Mutation:  20 strains or lines available
Notes
The oxygen affinity of hemoglobin is increased in mutant mice. Because erythrocytes give up oxygen to the tissues less readily, polycythemia, with marked increases in red cell number, packed cell volume, and blood hemoglobin, results (J:13920). This murine polycythemia is homologous with hemoglobin Ranier in human (OMIM 141900, see .0232).

References
Original:  J:7972 Peters J, et al., A mouse beta-globin mutant that is an exact model of hemoglobin Rainier in man. Genetics. 1985 Aug;110(4):709-21
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory