About   Help   FAQ
Spontaneous Allele Detail
Symbol: Axin1Fu
Name: axin 1; fused
MGI ID: MGI:1856035
Synonyms: Fu, Tf
Gene: Axin1  Location: Chr17:26138688-26195811 bp, + strand  Genetic Position: Chr17, 13.07 cM
Strain of Origin:  Bussey Institution stock
Allele Type:    Spontaneous
Mutation:    Transposon insertion
Mutation detailsThe mutation is an IAP retrotransposon insertion within the sixth intron that results in the production of wild-type transcripts as well as mutant transcripts that initiate at both the authentic promoter and the 3'-most long terminal repeat of the insertion. (J:41619, J:43298, J:72363)
Inheritance:    Semidominant
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Axin1 Mutation:  3 strains or lines available
Gametic imprinting has been detected for Axin1Fu (J:11139), and the locus may be affected by inherited inactivation (J:6577). Penetrance is affected by the genetic background, although expressivity is not. A suppressor gene in C57BL/6 decreases the penetrance of Axin1Fu in hybrids (J:11139). The suppressor gene did not affect penetrance of Axin1Fu in mice chimeric between C57BL/6 and a stock carrying Axin1Fu (J:19657).
Original:  J:12953 Reed SC, The Inheritance and Expression of Fused, a New Mutation in the House Mouse. Genetics. 1937 Jan;22(1):1-13
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory