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Lama2dy
Spontaneous Allele Detail
Summary
Symbol: Lama2dy
Name: laminin, alpha 2; dystrophia muscularis
MGI ID: MGI:1856026
Synonyms: dy
Gene: Lama2  Location: Chr10:26857281-27493021 bp, - strand  Genetic Position: Chr10, 14.23 cM, cytoband A4-B1
Alliance: Lama2dy page
Lama2dy/Lama2dy and control

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  129P1/Re
Mutation
description
Allele Type:    Spontaneous
Mutation:    Undefined
 
Mutation detailsAnalysis of Lama2 expression of dystrophic dy mice revealed a specific deficiency of this mRNA in skeletal muscle, cardiac muscle, and peripheral nerve. (J:18187, J:44989)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 9 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 18 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Lama2dy
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lama2 Mutation:  177 strains or lines available
Notes
This mutation arose spontaneously in the 129/Re inbred strain at The Jackson Laboratory in 1951.
References
Original:  J:13125 Michelson AM, et al., Dystrophia muscularis: a hereditary primary myopathy in the house mouse. Proc Natl Acad Sci U S A. 1955 Dec 15;41(12):1079-1084
All:  77 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory