Clcn1^adr-K
Chemically induced Allele Detail

Summary

• Symbol: Clcn1^adr-K
• Name: chloride channel, voltage-sensitive 1; myotonia K
• MGI ID: MGI:1855956
• Synonyms: adr^K
• Gene: Clcn1 Location: Chr6:42263619-42292690 bp, + strand Genetic Position: Chr6, 20.57 cM
• Alliance: Clcn1^adr-K page

Mutation origin

• Strain of Origin: C57BL/6 x CBA/CaJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T-to-C transition mutation is predicted to cause an isoleucine to threonine substitution at codon 553. This is a conserved residue within a highly conserved region of the encoded protein. Northern analyses of adult skeletal muscle using a 5' and a 3' rat cDNA Clcn1 probe detected wild-type size transcript in homozygous mutant mice (J:752). (J:16954)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcn1 Mutation: 71 strains or lines available

Notes

Allelism testing showed this mutation to be allelic to other Clcn1 mutations (J:14986).

References

• Original: J:17757 Neumann P, et al., A new allele of adr. Mouse News Lett. 1989;83:157
• All: 4 reference(s)