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Spontaneous Allele Detail
Symbol: a
Name: nonagouti
MGI ID: MGI:1855937
Gene: a  Location: Chr2:154791402-155051012 bp, + strand  Genetic Position: Chr2, 76.83 cM
Strain of Origin:  old mutant of the mouse fancy
Allele Type:    Spontaneous
Mutation:    Viral insertion
Mutation detailsCharacterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host integration site is the same as for at-2Gso and Aw-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. (J:16984, J:24934)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 54 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 177 strains available      Cell Lines: 1 line available
Carrying any a Mutation:  349 strains or lines available
Phenotypic Similarity to Human Syndrome: Metabolic Syndrome in mice homozygous for Apoetm1Unc and heterozygous for Ay and a (J:177084)

Original:  J:12970 Markert CL, et al., The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics. 1956 May;41(3):429-50
All:  91 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory