Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cthrc1tm1.2Suna
Name:	collagen triple helix repeat containing 1; targeted mutation 1.1, Sunao Takeshita
MGI ID:	MGI:5544611
Gene:	Cthrc1  Location: Chr15:38940327-38950516 bp, + strand  Genetic Position: Chr15, 15.35 cM, cytoband C
Alliance:	Cthrc1tm1.2Suna page

Germline Transmission:	Earliest citation of germline transmission: J:201631
Parent Cell Line:	iTL BA1 (ES Cell)
Strain of Origin:	(C57BL/6NTac x 129S6/SvEvTac)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 2. A loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exon 2. RT-PCR confirmed the absence of transcript expression in the bone. (J:201631)

Generation of the Cthrc1tm1.1Suna and Cthrc1tm1.2Suna alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cthrc1 Mutation:	30 strains or lines available

Original:	J:201631 Takeshita S, et al., Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation. J Clin Invest. 2013 Sep 3;123(9):3914-24
All:	1 reference(s)