Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vdrtm2.1Ska
Name:	vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 2.1, Shigeaki Kato
MGI ID:	MGI:5501514
Synonyms:	VDRL-, Vdrtm1.1Pcn
Gene:	Vdr  Location: Chr15:97752308-97806177 bp, - strand  Genetic Position: Chr15, 53.85 cM
Alliance:	Vdrtm2.1Ska page

Germline Transmission:	Earliest citation of germline transmission: J:196471
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 3. A floxed neomycin (neo) resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and exon 3. (J:196471)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vdr Mutation:	35 strains or lines available

Original:	J:196471 Yamamoto Y, et al., Vitamin D receptor in osteoblasts is a negative regulator of bone mass control. Endocrinology. 2013 Mar;154(3):1008-20
All:	2 reference(s)