Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tbc1d4tm1.2Arte
Name:	TBC1 domain family, member 4; targeted mutation 1.2, TaconicArtemis
MGI ID:	MGI:5478502
Gene:	Tbc1d4  Location: Chr14:101679796-101846627 bp, - strand  Genetic Position: Chr14, 50.9 cM
Alliance:	Tbc1d4tm1.2Arte page

Germline Transmission:	Earliest citation of germline transmission: J:194026
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 10 was replaced with an FRT-flanked neo cassette with a 5' loxP site and a modified exon 10 in which nucleotide substitutions result in the amino acid substitution of alanine for threonine at position 649 (T649A) followed by a loxP site. Flp-mediate recombination removed the neo cassette. Cre-mediated recombination removed the modified exon 10. Western blot analysis confirmed the absence of protein expression in the soleus, gastrocnemius, tibialis anterior, adipose and heart. (J:194026)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbc1d4 Mutation:	51 strains or lines available

Original:	J:194026 Wang HY, et al., AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Biochem J. 2013 Jan 15;449(2):479-89
All:	3 reference(s)