Psmc4tm1.2Ryot
Targeted Allele Detail
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Symbol: |
Psmc4tm1.2Ryot |
Name: |
proteasome (prosome, macropain) 26S subunit, ATPase, 4; targeted mutation 1.2, Ryosuke Takahashi |
MGI ID: |
MGI:5470094 |
Synonyms: |
Rpt3delta |
Gene: |
Psmc4 Location: Chr7:27741127-27749517 bp, - strand Genetic Position: Chr7, 16.11 cM
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Alliance: |
Psmc4tm1.2Ryot page
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Limb clasping and severe kyphosis in Psmc4tm1.1Ryot/Psmc4tm1.2Ryot Tg(SLC18A3-cre)KMisa/0 mice
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:193770
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Parent Cell Line: |
RENKA (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 7. An additional loxP site was inserted downstream of exon 10. Cre-mediated recombination removed the neo cassette and exons 7 through 10.
(J:193770)
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Generation of the Psmc4tm1.1Ryot and Psmc4tm1.2Ryot alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Psmc4 Mutation: |
18 strains or lines available
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Original: |
J:193770 Tashiro Y, et al., Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J Biol Chem. 2012 Dec 14;287(51):42984-94 |
All: |
1 reference(s) |
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