Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Ttll5tm1.1N Name: tubulin tyrosine ligase-like family, member 5; targeted mutation 1.1, National Institutes of Health MGI ID: MGI:5467943 Synonyms: Stamptm Gene: Ttll5  Location: Chr12:85871417-86100534 bp, + strand  Genetic Position: Chr12, 39.81 cM, cytoband D3 Alliance: Ttll5tm1.1N page

Disrupted axoneme in Ttll5tm1.1N/Ttll5tm1.1N sperm tails Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:94077
Parent Cell Line:	iTL BA1 (ES Cell)
Strain of Origin:	(C57BL/6NTac x 129S6/SvEvTac)F1

Allele Type:    Targeted (Hypomorph) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 23. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 24. Cre-mediated recombination removed exon 23, exon 24 and the neomycin resistance cassette. Because of the possibility of truncated protein expression, this allele could be hypomorphic. (J:94077)

Generation of the Ttll5tm1N and Ttll5tm1.1N alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ttll5 Mutation:	66 strains or lines available

Original:	J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:	5 reference(s)