Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Kdm6atm1.2Kaig Name: lysine (K)-specific demethylase 6A; targeted mutation 1.2, Kai Ge MGI ID: MGI:5448825 Synonyms: UTX- Gene: Kdm6a  Location: ChrX:18028814-18146175 bp, + strand  Genetic Position: ChrX, 13.45 cM Alliance: Kdm6atm1.2Kaig page

Neural tube closure, cardiac development and hematopoiesis defects in Kdm6atm1.2Kaig/Kdm6atm1.2Kaig females Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:190157
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed the modified exon 24. Western blot analysis confirmed the absence of protein expression in embryonic stem cells. (J:190157)

Generation of the Kdm6atm1.2Kaig allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm6a Mutation:	38 strains or lines available

Original:	J:190157 Wang C, et al., UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15324-9
All:	1 reference(s)