Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hcn3tm1.1Biel
Name:	hyperpolarization-activated, cyclic nucleotide-gated K+ 3; targeted mutation 1.1, Martin Biel
MGI ID:	MGI:5443894
Gene:	Hcn3  Location: Chr3:89054082-89067538 bp, - strand  Genetic Position: Chr3, 39.01 cM, cytoband F2
Alliance:	Hcn3tm1.1Biel page

Germline Transmission:	Earliest citation of germline transmission: J:188823
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 2. An floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:188823)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcn3 Mutation:	25 strains or lines available

Original:	J:188823 Fenske S, et al., HCN3 contributes to the ventricular action potential waveform in the murine heart. Circ Res. 2011 Oct 14;109(9):1015-23
All:	5 reference(s)