Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Shank2tm1Mgle
Name:	SH3 and multiple ankyrin repeat domains 2; targeted mutation 1, Min Goo Lee
MGI ID:	MGI:5437479
Gene:	Shank2  Location: Chr7:143555665-143978231 bp, + strand  Genetic Position: Chr7, 88.45 cM
Alliance:	Shank2tm1Mgle page

Germline Transmission:	Earliest citation of germline transmission: J:186718
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An approximately 3.1 kb genomic fragment including exons 6 and 7 was replaced with a floxed neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in the brains of homozygous mice. (J:186718)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shank2 Mutation:	91 strains or lines available

Original:	J:186718 Won H, et al., Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature. 2012 Jun 14;486(7402):261-5
All:	22 reference(s)