Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Mcoln3tm1.1Jga
Name:	mucolipin 3; targeted mutation 1.1, Jaime Garcia-Anoveros
MGI ID:	MGI:5437317
Synonyms:	Trpml3-
Gene:	Mcoln3  Location: Chr3:145823205-145847561 bp, + strand  Genetic Position: Chr3, 71.03 cM
Alliance:	Mcoln3tm1.1Jga page

Germline Transmission:	Earliest citation of germline transmission: J:187348
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: LoxP sites were inserted in intron 6 and in intron 8. Subsequent cre expression excised exons 7 and 8 and caused a frame shift in exon 9 resulting in multiple stop codons. PCR analysis of reverse transcribed RNA confirmed the absence of transcription. (J:187348)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mcoln3 Mutation:	35 strains or lines available

Original:	J:187348 Castiglioni AJ, et al., Expression and vesicular localization of mouse Trpml3 in stria vascularis, hair cells, and vomeronasal and olfactory receptor neurons. J Comp Neurol. 2011 Apr 15;519(6):1095-114
All:	4 reference(s)