Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fcgr2btm1.2Rav
Name:	Fc receptor, IgG, low affinity IIb; targeted mutation 1.2, Jeffrey V Ravetch
MGI ID:	MGI:5432537
Gene:	Fcgr2b  Location: Chr1:170786186-170804116 bp, - strand  Genetic Position: Chr1, 78.02 cM
Alliance:	Fcgr2btm1.2Rav page

Germline Transmission:	Earliest citation of germline transmission: J:174675
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of the exon encoding the first extracellular domain. A floxed neo cassette was inserted downstream of the exon encoding the transmembrane domain. Cre mediated recombination removed the neo cassette and the exons. (J:174675, J:209892)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fcgr2b Mutation:	49 strains or lines available

Original:	J:174675 Li F, et al., Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science. 2011 Aug 19;333(6045):1030-4
All:	6 reference(s)