Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Kiss1rtm1.1Lex
Name:	KISS1 receptor; targeted mutation 1.1, Lexicon Genetics
MGI ID:	MGI:5316416
Synonyms:	Gpr54-
Gene:	Kiss1r  Location: Chr10:79752805-79758107 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Kiss1rtm1.1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:181650
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted into exon 1. An additional loxP site and a lacZ with a nuclear localization sequence was inserted downstream of exon 5. Cre-mediated recombination removed the coding sequence. RT-PCR confirmed the absence of transcript expression in the hypothalamus. (J:181650)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

22 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kiss1r Mutation:	20 strains or lines available

Original:	J:181650 Garcia-Galiano D, et al., Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology. 2012 Jan;153(1):316-28
All:	7 reference(s)