Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Casp7tm1.1Acau
Name:	caspase 7; targeted mutation 1.1, Anje Cauwels
MGI ID:	MGI:5308651
Gene:	Casp7  Location: Chr19:56385561-56430776 bp, + strand  Genetic Position: Chr19, 51.84 cM
Alliance:	Casp7tm1.1Acau page

Germline Transmission:	Earliest citation of germline transmission: J:179279
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 4 and a floxed neo cassette was inserted downstream of exon 5 via homologous recombination. Cre mediated recombination removed exons 4 and 5 and the neo cassette. Western blot analysis confirmed the absence of protein in the liver, lung, blood, and intestine of homozygous mice. (J:179279)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp7 Mutation:	16 strains or lines available

Original:	J:179279 Duprez L, et al., RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome. Immunity. 2011 Dec 23;35(6):908-18
All:	2 reference(s)