Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tet2tm1.2Rao
Name:	tet methylcytosine dioxygenase 2; targeted mutation 1.2, Anjana Rao
MGI ID:	MGI:5285413
Gene:	Tet2  Location: Chr3:133169438-133250882 bp, - strand  Genetic Position: Chr3, 61.84 cM
Alliance:	Tet2tm1.2Rao page

Germline Transmission:	Earliest citation of germline transmission: J:175222
Parent Cell Line:	ART B6-3, B6-3 (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 8 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 10 via homologous recombination. Recombinase mediated recombination removed exons 8 - 10 and the neo cassette. (J:175222)

Targeting strategy to generate the Tet2tm1.1Rao and Tet2tm1.2Rao alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tet2 Mutation:	778 strains or lines available

Original:	J:175222 Ko M, et al., Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14566-71
All:	35 reference(s)