Stab2tm1.1Cger
Targeted Allele Detail
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| Symbol: |
Stab2tm1.1Cger |
| Name: |
stabilin 2; targeted mutation 1.1, Cyrill Geraud |
| MGI ID: |
MGI:5000471 |
| Gene: |
Stab2 Location: Chr10:86677062-86843889 bp, - strand Genetic Position: Chr10, 43.14 cM
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| Alliance: |
Stab2tm1.1Cger page
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Liver fibrosis in Stab1tm1.1Cger/Stab1tm1.1Cger Stab2tm1.1Cger/Stab2tm1.1Cger mice
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:171818
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neo cassette with a 5' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Cre-mediated recombination removed the neo cassette and exon 1. Immunohistochemistry confirmed the absence of protein expression in the liver.
(J:171818)
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Generation of the Stab2tm1.1Cger allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Stab2 Mutation: |
136 strains or lines available
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| Original: |
J:171818 Schledzewski K, et al., Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest. 2011 Feb 1;121(2):703-14 |
| All: |
4 reference(s) |
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Analysis Tools
