Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myh14tm1Rsad
Name:	myosin, heavy polypeptide 14; targeted mutation 1, Robert S Adelstein
MGI ID:	MGI:4887985
Synonyms:	C-
Gene:	Myh14  Location: Chr7:44255227-44320267 bp, - strand  Genetic Position: Chr7, 28.85 cM, cytoband B2
Alliance:	Myh14tm1Rsad page

Germline Transmission:	Earliest citation of germline transmission: J:168304
Parent Cell Line:	CMT-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 0.3 kb fragment including the 157 bp exon 3 was replaced by a loxP-flanked neomycin resistance cassette via homologous recombination. Deletion of exon 3 was confirmed by Southern blot. Immunoblot analysis from lungs confirmed the absence of protein. (J:168304)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myh14 Mutation:	81 strains or lines available

Original:	J:168304 Ma X, et al., Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis. Mol Biol Cell. 2010 Nov;21(22):3952-62
All:	4 reference(s)