Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Mylk3tm1Jtst Name: myosin light chain kinase 3; targeted mutation 1, James Stull MGI ID: MGI:4881762 Synonyms: cMLCKneo Gene: Mylk3  Location: Chr8:86050933-86112969 bp, - strand  Genetic Position: Chr8, 41.61 cM Alliance: Mylk3tm1Jtst page

Mylk3tm1Jtst/Mylk3+ and Mylk3tm1Jtst/Mylk3tm1Jtst mice exhibit hypertrophic hearts Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:167590
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 4, and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. The absence of protein expression was confirmed by western blot analysis on ventricular and atrial extracts. (J:167590)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mylk3 Mutation:	42 strains or lines available

Original:	J:167590 Ding P, et al., Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo. J Biol Chem. 2010 Dec 24;285(52):40819-29
All:	1 reference(s)