Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Faddtm1.1Mpa
Name:	Fas associated via death domain; targeted mutation 1.1, Manolis Pasparakis
MGI ID:	MGI:4880717
Gene:	Fadd  Location: Chr7:144132060-144136178 bp, - strand  Genetic Position: Chr7, 88.85 cM
Alliance:	Faddtm1.1Mpa page

Germline Transmission:	Earliest citation of germline transmission: J:167475
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination removed exon 2. The absence of protein expression was confirmed by western blot analysis on embryonic fibroblast extracts. (J:167475)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fadd Mutation:	19 strains or lines available

Original:	J:167475 Mc Guire C, et al., Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination. J Immunol. 2010 Dec 15;185(12):7646-53
All:	2 reference(s)