Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hif1antm1.2Rsjo
Name:	hypoxia-inducible factor 1, alpha subunit inhibitor; targeted mutation 1.2, Randall S Johnson
MGI ID:	MGI:4459899
Synonyms:	FIHdelta2
Gene:	Hif1an  Location: Chr19:44551293-44564713 bp, + strand  Genetic Position: Chr19, 37.98 cM, cytoband D1
Alliance:	Hif1antm1.2Rsjo page

Germline Transmission:	Earliest citation of germline transmission: J:160941
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neo cassette was inserted within intron 1, with an additional loxP site with intron 2. The selection cassette and exon 2 were removed by cre mediated recombination. Western blot confirmed absence of protein in whole embryo lysates. (J:160941)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	71 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hif1an Mutation:	15 strains or lines available

Original:	J:160941 Zhang N, et al., The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010 May 5;11(5):364-78
All:	4 reference(s)