Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Ehd1tm1.2Haba Name: EH-domain containing 1; targeted mutation 1.2, Hamid Band MGI ID: MGI:4458098 Synonyms: Ehd1- Gene: Ehd1  Location: Chr19:6326926-6350126 bp, + strand  Genetic Position: Chr19, 4.4 cM Alliance: Ehd1tm1.2Haba page

Ehd1tm1.2Haba/Ehd1tm1.2Haba mice are small and males exhibit small testis Show the 5 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:160452
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Two loxP sites were introduced to flank exon 1 by recombineering. An engineered FRT-Neo-FRT selection cassette was immediately preceding the second loxP site. The first exon was deleted by Cre-mediated recombination. RT-PCR and immunostaining confirmed the absence of mRNA and protein expression in the testis of homozygous mice. Western blots performed on lysates of mouse lung, kidney, heart, spleen, and testis confirmed the loss of the protein expression. (J:160452)

Generation of the Ehd1tm1.2Haba and Ehd1tm1.1Haba alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ehd1 Mutation:	38 strains or lines available

Original:	J:160452 Rainey MA, et al., The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice. BMC Dev Biol. 2010;10:37
All:	7 reference(s)