Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Acdtm1.2Cek
Name:	adrenocortical dysplasia; targeted mutation 1.2, Catherine Keegan
MGI ID:	MGI:4456178
Synonyms:	Acdtm1.2Tdl, TPP1DEL
Gene:	Acd  Location: Chr8:106424789-106427748 bp, - strand  Genetic Position: Chr8, 53.04 cM
Alliance:	Acdtm1.2Cek page

Germline Transmission:	Earliest citation of germline transmission: J:160503
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre mediated recombination removed exons 3 through 8 from Tpp1tm1.1Tdl. The predicted protein is expected to be severely truncated containing the N-terminal 79 amino acids and 17 out-of-frame amino acids prior to a stop codon. (J:160503)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acd Mutation:	22 strains or lines available

Original:	J:160503 Kibe T, et al., Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol Cell Biol. 2010 Feb;30(4):1059-66
All:	1 reference(s)