Lrp4tm2Her
Targeted Allele Detail
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Symbol: |
Lrp4tm2Her |
Name: |
low density lipoprotein receptor-related protein 4; targeted mutation 2, Joachim Herz |
MGI ID: |
MGI:4455050 |
Synonyms: |
Lrp4- |
Gene: |
Lrp4 Location: Chr2:91287856-91344124 bp, + strand Genetic Position: Chr2, 50.63 cM
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Alliance: |
Lrp4tm2Her page
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Unilateral and bilateral kidney agenesis in Lrp4tm2Her/Lrp4tm2Her mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:156471
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S/SvEv
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Exon 1, which encodes the signal peptide and the initiating ATG, was replaced with a neomycin stop cassette. No residual functional protein can be generated.
(J:156471, J:160547)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lrp4 Mutation: |
97 strains or lines available
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Original: |
J:156471 Ohazama A, et al., A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):92-7 |
All: |
4 reference(s) |
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