Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tra2btm1.2Bwir
Name:	transformer 2 beta; targeted mutation 1.2, Brunhilde Wirth
MGI ID:	MGI:4450921
Synonyms:	Sfrs10-
Gene:	Tra2b  Location: Chr16:22063302-22084755 bp, - strand  Genetic Position: Chr16, 13.18 cM
Alliance:	Tra2btm1.2Bwir page

Germline Transmission:	Earliest citation of germline transmission: J:159448
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A single loxP site and an frt flanked neomycin resistance cassette were inserted upstream of exon 4 and a second loxP site was inserted downstream of the exon. Exon 4 and the neomycin resistance cassette were excised in mice by crossing to the cre deleter line, Tg(CMV-cre)1Cgn. Deletion of exon 4 results in a frameshift and a premature stop codon in exon 5. (J:159448)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tra2b Mutation:	23 strains or lines available

Original:	J:159448 Mende Y, et al., Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing. Hum Mol Genet. 2010 Jun 1;19(11):2154-67
All:	1 reference(s)