Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bhlhe22tm1Meg
Name:	basic helix-loop-helix family, member e22; targeted mutation 1, Michael E Greenberg
MGI ID:	MGI:4440742
Synonyms:	Bhlhb5-
Gene:	Bhlhe22  Location: Chr3:18108489-18111678 bp, + strand  Genetic Position: Chr3, 4.98 cM, cytoband A2
Alliance:	Bhlhe22tm1Meg page

Germline Transmission:	Earliest citation of germline transmission: J:158273
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The single exon of Bhlhe22 was replaced with a PGK-neo cassette by homologous recombination in ES cells, resulting in a null allele. (J:158273)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bhlhe22 Mutation:	12 strains or lines available

Original:	J:158273 Ross SE, et al., Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010 Mar 25;65(6):886-98
All:	4 reference(s)