Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bidtm1.1Ast
Name:	BH3 interacting domain death agonist; targeted mutation 1.1, Andreas Strasser
MGI ID:	MGI:4440571
Synonyms:	Bid-
Gene:	Bid  Location: Chr6:120870080-120894074 bp, - strand  Genetic Position: Chr6, 57.02 cM
Alliance:	Bidtm1.1Ast page

Germline Transmission:	Earliest citation of germline transmission: J:158191
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The allele was created by crossing heterozygous Bidtm1Ast mice with Tg(CMV-cre)1Cgn cre deleter mice to remove neo cassette, leaving a single loxP site and deleting approximately 4.5 kb region of the bid locus containing exons 1 and 2 plus part of exon 3, including the crucial BH3 domain. Western blot analysis on spleen and thymus samples and thymocytes derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:158191)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bid Mutation:	44 strains or lines available

Original:	J:158191 Kaufmann T, et al., The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell. 2007 Apr 20;129(2):423-33
All:	15 reference(s)