Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Mid1tm1Mero
Name:	midline 1; targeted mutation 1, Germana Meroni
MGI ID:	MGI:4437430
Gene:	Mid1  Location: ChrX:168468195-168773794 bp, + strand  Genetic Position: ChrXY, 79.19 cM
Alliance:	Mid1tm1Mero page

Germline Transmission:	Earliest citation of germline transmission: J:157828
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A fragment of the first coding exon including the first ATG was replaced with a neo selection cassette. RT-PCR and immunoblot analysis show the complete absence of the transcript and protein in embryos and adult brains, respectively. (J:157828)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mid1 Mutation:	195 strains or lines available

Original:	J:157828 Lancioni A, et al., Lack of Mid1, the mouse ortholog of the Opitz syndrome gene, causes abnormal development of the anterior cerebellar vermis. J Neurosci. 2010 Feb 24;30(8):2880-7
All:	1 reference(s)