Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dhx58tm1Aki
Name:	DExH-box helicase 58; targeted mutation 1, Shizuo Akira
MGI ID:	MGI:4437255
Gene:	Dhx58  Location: Chr11:100585710-100595097 bp, - strand  Genetic Position: Chr11, 63.52 cM
Alliance:	Dhx58tm1Aki page

Germline Transmission:	Earliest citation of germline transmission: J:156867
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1-5 were replaced by a neo cassette. Northern blot analysis failed to detect mRNA in homozygous MEFs. (J:156867)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dhx58 Mutation:	36 strains or lines available

Original:	J:156867 Satoh T, et al., LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7
All:	1 reference(s)