Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chrm1tm2.1Stl
Name:	cholinergic receptor, muscarinic 1, CNS; targeted mutation 2.1, Susumu Tonegawa
MGI ID:	MGI:4437231
Gene:	Chrm1  Location: Chr19:8641369-8660970 bp, + strand  Genetic Position: Chr19, 5.44 cM
Alliance:	Chrm1tm2.1Stl page

Germline Transmission:	Earliest citation of germline transmission: J:156540
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready) Mutations:    Insertion, Intragenic deletion   Mutation details: The single coding exon 1 was flanked by loxP sites and an FRT flanked neo was inserted within intron 1 by homologous recombination. Flp mediated recombination removed the selection cassette. (J:156540)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrm1 Mutation:	26 strains or lines available

Original:	J:156540 Kamsler A, et al., Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1618-23
All:	9 reference(s)